Disease gene blocker sneaks past cell defences

 作者:隆历璐     |      日期:2019-03-01 06:16:02
By Linda Geddes SNIPPETS of RNA that switch off disease-causing genes can now slip into cells unaided. This could help efforts to use RNA interference (RNAi) to treat diseases such as cancer and diabetes. For a gene to be expressed as a protein, it must first be copied into messenger RNA (mRNA). RNAi blocks this process by sending in RNA snippets that bind to specific mRNAs. To do this, the gene-blocking RNA must first get into the cell. A variety of elaborate strategies have been suggested as ways to get it there,